Not all motherboards having multiple PCI Express x16 graphics card slots support Crossfire as some of them support SLI only. The other major requirement of Crossfire setup is Crossfire Ready Motherboard or Motherboard that supports CrossFire. You can look at the compatibility list below of CrossFire graphics cards showing which AMD graphics cards are compatible with another in CrossFire configuration. Unlike Nvidia SLI, two graphics cards having different GPUs may work together in AMD CrossFire mode depending on their compatibility. The first requirement for setting up a CrossFire configuration is two or more CrossFire Ready AMD Graphics Cards (up 4 GPUs). Here are the various requirements for setting up a CrossFire setup on your computer using multiple GPUs.
